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Wound Healing 101 Phases of Wound Healing Inflammatory Phase The inflammatory phase, often referred to as the reaction phase, occurs at the time of injury and for up to 5 days. The first phase is characterized by vascular responses – vasodilation and hemostasis, followed by cellular responses – when leukocytes (PMNs and macrophages) migrate to the wound, cause inflammation, fight infection and remove debris. Proliferative Phase Also referred to as the regeneration phase, the second phase takes place 2 days to 3 weeks following injury. In this "building" phase, processes promote epithelialization, angiogenesis, granulation tissue formation, and collagen deposition. A balance of collagen synthesis and collagen lysis takes place. Metabolic substrates, oxygen concentration, and growth factors are highly influential in the processes, as is a moist environment. Adequate blood supply also is essential for healing, allowing for cell migration, replication, infection resistance, and development of matrix components. Remodeling Phase The remodeling phase, or maturational phase, extends from 3 weeks post injury to 2 years. During this phase, the wound undergoes further contraction, when fibroblasts are converted to myofibroblasts. Granulation tissue is gradually replaced by connective tissue. Collagen fibers increase in thickness and are re-oriented along the stress line of the wound, increasing tensile strength. Scar tissue, however, never attains the strength of original tissue. On average, chronic wounds regain 50% of strength in 3 weeks. Final tensile strength reaches 70 - 90% over 2 years. |
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Prospera phone 888-408-NPWT (6798) fax 888-674-NPWT (6798) |
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